Synlett 2019; 30(07): 863-867
DOI: 10.1055/s-0037-1611748
letter
© Georg Thieme Verlag Stuttgart · New York

A One-Pot Sonogashira Coupling and Annulation Reaction: An Efficient Route toward 4H-Quinolizin-4-ones

Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou, Jiangxi, 341000, P. R. of China   Email: chenzwang@gnnu.cn   Email: yemin811@gnnu.cn
,
Tanggao Liu
,
Xiaoyue Ma
,
Pei Liang
,
Lipeng Long
,
Min Ye*
› Author Affiliations

The authors thank the NSF of Jiangxi Province (20171ACB21048), the NSF of Jiangxi Provincial Education Department (GJJ160924), the Innovation Fund of Jiangxi Province (YC2018-S385), and University Students’ Innovative Undertaking of Gannan Normal University (201710418007) for financial support.
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Publication History

Received: 20 January 2019

Accepted after revision: 08 February 2019

Publication Date:
19 March 2019 (online)


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Abstract

An efficient one-pot Sonogashira coupling and annulation reaction affording 4H-quinolizin-4-ones in moderate to excellent yields is described. A variety of substituted iodoarenes and 2-alkylazaarenes were well tolerated, and especially the unsaturated double and triple bonds were compatible under the standard conditions.

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